The Pra Basin in Ghana is well-known for its abundant mineral resources, dense

forest coverage, and fertile soil. The region faces major water management challenges

due to illegal mining practices, resulting in surface water pollution and necessitating

groundwater use as an alternate water source. Unfortunately, there is limited

information available regarding the chemical characteristics of groundwater in the

region, posing challenges for water management. This study examined the quality,

hydrochemical variability and geochemical processes driving the chemical evolution

of the groundwater. Samples of surface water and groundwater were collected and

analyzed for chemical parameters. We employed multivariate statistics, including

cluster and factor analysis, to identify regional variations and interrelationships

among the parameters. The resulting clusters were used to formulate a hypothetical

groundwater flow path to model the geochemical reactions that control the

groundwater composition using combinatorial inverse modelling based on the local

thermodynamic equilibrium hypothesis. The weathering of silicate minerals,

including albite, anorthite, chalcedony, and k-feldspar, was found to be the dominant

process driving the groundwater's chemical evolution. Models adequately predicted

the composition of groundwater along the flow path and serve as a guide for the

development of sustainable water resource management strategies for the catchment.

Overall, our modelling approach presented here can be useful in regions with large

variability in water chemistry and limited knowledge of aquifer mineralogy.