figure3. Decrease in size and colour of facial rash with minimal ulcers. Normal lips appearanceDiscussion: Ibuprofen, a widely used nonsteroidal anti-inflammatory drug (NSAID), is generally considered safe for pain relief and inflammation. However, in rare cases, its use has been associated with severe adverse reactions, including Stevens-Johnson Syndrome (SJS), a potentially life-threatening skin condition (8). SJS is characterized by a severe and painful rash that can lead to the detachment of the outer layer of the skin (9). While it is more commonly linked to certain infections and other medications, including some antibiotics and anticonvulsants, cases of SJS associated with ibuprofen use have been reported. Middle-aged individuals, who might assume they are beyond the susceptibility to severe drug reactions often associated with younger populations, can find themselves facing unexpected challenges (5,7). The onset of SJS is typically abrupt, starting with flu-like symptoms and a rash that progresses rapidly. The severity of SJS requires immediate medical attention (9). The link between ibuprofen and SJS is not fully understood, and the reaction seems to be idiosyncratic, occurring in only a small percentage of individuals. Genetic factors may play a role in predisposing certain people to such severe reactions. Given the widespread use of ibuprofen for various conditions, including arthritis and pain management, understanding the potential risks is crucial. Patients, especially those in middle age, should be aware of the signs and symptoms of severe adverse reactions and seek medical attention if they experience unusual skin rashes, blistering, or mucosal involvement (10). Healthcare providers must weigh the benefits of ibuprofen against the potential risks, particularly in individuals with a history of adverse reactions or known risk factors. Communication between patients and healthcare professionals is vital to ensure informed decision-making regarding medication choices (10).