Infections
In a mouse model of recurrent skin and skin structure infections, macrophage memory reduced the severity of skin damage and promote an increase in the production of cytokines associated with skin protection and prevention of dissemination. Furthermore, the adoptive transfer of trained macrophages into naïve skin has also been established to afford protective efficacy 56. In addition, trained macrophages of mice that had previously been infected withS. aureus , have been observed to be associated with more rapid monocyte recruitment, enhanced bactericidal effects, improved healing, and the enhanced resistance of these mice to secondary infections 57.