Infections
In a mouse model of recurrent skin and skin structure infections,
macrophage memory reduced the severity of skin damage and promote an
increase in the production of cytokines associated with skin protection
and prevention of dissemination. Furthermore, the adoptive transfer of
trained macrophages into naïve skin has also been established to afford
protective efficacy 56. In addition, trained
macrophages of mice that had previously been infected withS. aureus , have been
observed to be associated with more rapid monocyte recruitment, enhanced
bactericidal effects, improved healing, and the enhanced resistance of
these mice to secondary infections 57.