AdipoAI increases AdipoR1-PGC1-a expression in adipose tissues.
As PGC1a (pPARGC1a) regulation is involved in lipid metabolism in muscle
adipocytes (Bogacka, Xie, Bray, & Smith, 2005; Liang & Ward, 2006; Lin
et al., 2002; Patti et al., 2003). We assume that AdipoAI and AdipoRON
oral administration regulates adiponectin and PGC1a expression levels in
white adipose tissue (WAT). In WAT AdipoAI and AdipoRON both increase
AdipoR1, pPARGC1a, PPARA gene expression levels in comparison to DIO
mice (Fig 5A, C & D). Higher gene expression of all the three tested
gene was observed in AdipoAI treated group, suggesting that AdipoAI
could activate adiponectin signaling pathways through AdipoR1 and lower
doses of AdipoAI may influence the lipid metabolism in WAT which could
be a potential target.