AdipoAI administration improved insulin resistance and glucose tolerance in DIO mice models
The DIO mouse models were subjected to glucose and insulin tolerance test in accordance with our perceived plan of interventional strategy for developing T2D pathology (Fig 2A, B). OGTT showed time dependent decrease in serum glucose profile for AdipoAI and AdipoRON groups when compared to those of CMC (Carboxymethylcellulose) groups (Fig 2A). Further, insulin tolerance test resulted in gradual reduction in the levels of serum glucose in AdipoAI and AdipoRON groups when compared to that of CMC group suggesting that AdipoAI have comparable beneficial features as that of AdipoRON (Fig 2B).