Figure 3. Oral Glucose tolerance (OGTT) and Insulin tolerance test (ITT) test at 20 and 21 weeks in diet induced obesity (DIO) mice models for accessing AdipoAI efficacy (A) Mice were starved overnight, and oral administration of glucose (1mg/kg) were given blood glucose levels were evaluated prior to dosing (0-15 min), and carefully monitored every 15 minutes time interval for a period of 120 mins, following oral administration. The AdipoAI (25 mg/kg) exposed mice models revealed a decreased in blood glucose levels and have similar profile of OGTT with respect to another established bioactive molecule such as AdipoRon (50 mg/kg). (B) Insulin tolerance test (0.75 IU insulin per kg body weight) was performed in AdipoAI and AdipoRON treated DIO mice models after 6 hours of fasting. Blood glucose was monitored at specific time interval (0 -120 mins) by using a sensitive glucometer depicting comparable curves of AdipoAI and AdipoRON. Data are represented as mean ± SD of 6 mice per group.; *p<0.05, **p<0.001 compared to CMC vehicle.