The aflatoxin B1-induced imidazole ring-opened guanine adduct: high mutagenic potential that is minimally affected by sequence context
Irina G. Minko1, Andrew H. Kellum, Jr2., Michael P. Stone2†, R. Stephen Lloyd1,3†
1 Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239
2 Department of Chemistry, Vanderbilt University, Nashville, TN
3 Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239
Correspondence to: R. Stephen Lloyd, Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, L606, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; Tel: + 1 503 494 9957; Fax: + 1 503 494 4278; Email: lloydst@ohsu.edu
Running title: Mutagenic potential of the aflatoxin B1-induced guanine adduct
Keywords: base substitution, hepatocellular carcinoma, replication bypass, COSMIC signature SBS24