The aflatoxin B1-induced imidazole ring-opened
guanine adduct: high mutagenic potential that is minimally affected by
sequence context
Irina G. Minko1, Andrew H. Kellum,
Jr2., Michael P. Stone2†, R. Stephen
Lloyd1,3†
1 Oregon Institute of Occupational Health Sciences,
Oregon Health & Science University, 3181 SW Sam Jackson Park Rd.,
Portland, OR 97239
2 Department of Chemistry, Vanderbilt University,
Nashville, TN
3 Department of Molecular and Medical Genetics, Oregon
Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR
97239
† Correspondence to: R. Stephen Lloyd, Oregon
Institute of Occupational Health Sciences, Oregon Health & Science
University, L606, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA;
Tel: + 1 503 494 9957; Fax: + 1 503 494 4278; Email:
lloydst@ohsu.edu
Running title: Mutagenic potential of the aflatoxin
B1-induced guanine adduct
Keywords: base substitution, hepatocellular carcinoma, replication
bypass, COSMIC signature SBS24