Abca1 |
HDL deficiency, foam cell accumulation |
|
PMID:
10760292 |
|
HDL cholesterol levels |
|
PMID: 18974039 |
Abca2 |
Multiple behavioral/neurological phenotypes |
Multiple
behavioral/neurological phenotypes |
|
|
Decreased body weight |
|
|
Abca3 |
Abnormal lung development, morphology |
|
|
Abca4 |
Abnormal dark adaptation, photoreceptor morphology and
degeneration |
Abnormal dark adaptation, photoreceptor morphology and
degeneration |
Abnormal dark adaptation, photoreceptor morphology and
degeneration |
|
Vertebral fusion, respiratory quotient |
|
|
Abca5 |
Abnormal liver morphology and physiology |
Lysosomal
disease-like symptoms. |
PMID: 15870284 |
|
Tremors, cardiomyopathy, absent thyroid gland, decreased thyroid
activity |
Tremors, cardiomyopathy, absent thyroid gland, decreased
thyroid activity |
Tremors, cardiomyopathy, absent thyroid gland,
decreased thyroid activity |
Abca6 |
Decreased circulating serum albumin, decreased total
protein and increased hematocrit |
Decreased circulating serum albumin,
decreased total protein and increased hematocrit |
jax.org/reference/J:211773 |
Abca7 |
Decreased HDL cholesterol, adipose tissue, kidney size |
Decreased HDL cholesterol, adipose tissue, kidney size |
|
Abca8a |
nd |
2 null alleles, no reported phenotype |
2 null
alleles, no reported phenotype |
Abca8b |
Decreased cholesterol, HDL cholesterol, LDL cholesterol,
and triglyceride levels |
Decreased cholesterol, HDL cholesterol, LDL
cholesterol, and triglyceride levels |
PMID:28882873 |
|
Abnormal eye morphology |
|
PMID:28882873 |
Abca9 |
Abnormal behavioral response to light |
Expression in
embryo mesenchyme and CNS |
jax.org/reference/J:211773 |
Abca12 |
Reddish, scaly, abnormal, tight skin |
|
jax.org/reference/J:161652 |
|
Dehydration, no suckling reflex |
|
jax.org/reference/J:262458 |
|
Surfactant deficiency, lamellar body, alveolar collapse |
Surfactant
deficiency, lamellar body, alveolar collapse |
jax.org/reference/J:139048 |
Abca13 |
Abnormal male genitalia morphology, decrease blood urea
nitrogen level |
Abnormal male genitalia morphology, decrease blood urea
nitrogen level |
jax.org/reference/J:211773 |
Abca14 |
Decreased total body fat amount |
Expression only in
reproductive tract |
jax.org/reference/J:211773 |
Abca15 |
nd |
Expression only in reproductive tract |
Expression
only in reproductive tract |
Abca16 |
nd |
Expression only in reproductive tract |
Expression
only in reproductive tract |
Abca17 |
Decreased circulating potassium level |
|
jax.org/reference/J:211773 |
Abcb1a |
Abnormal intestinal epithelium and ulcers, colitis |
Abnormal intestinal epithelium and ulcers, colitis |
|
|
Xenobiotic sensitity |
|
|
|
Hippocampal neuronal degeneration, tremors, catapsy |
Hippocampal
neuronal degeneration, tremors, catapsy |
|
|
Abnormal immunoglobulin and T cell levels |
Abnormal immunoglobulin
and T cell levels |
|
Abcb1b |
Abnormal xenobiotic sensitivity |
|
|
Tap1/Abcb2 |
Abnormal T cell levels, antigen presentation |
Abnormal T cell levels, antigen presentation |
|
Tap2/Abcb3 |
Abnormal T cell levels, antigen presentation |
Abnormal T cell levels, antigen presentation |
|
Abcb4 |
Abnormal bile secretion, bile salt level, gallstones |
Abnormal bile secretion, bile salt level, gallstones |
|
|
Decreased bone mineral density and morphology, calcium level |
Decreased bone mineral density and morphology, calcium level |
jax.org/reference/J:199949 |
|
Liver cirrhosis, |
|
|
Abcb5 |
Abnormal cornea and retina morphology |
|
jax.org/reference/J:213708 |
Abcb6 |
Abnormal erythropoiesis, mitochondrial physiology |
Abnormal erythropoiesis, mitochondrial physiology |
|
Abcb7 |
Prenatal, postnatal lethality, hemorrhage, liver
morphology |
Prenatal, postnatal lethality, hemorrhage, liver morphology |
|
Abcb8 |
Abnormal heart morphology, weight, cardiac output,
cardiomyopathy, heart iron levels |
Abnormal heart morphology, weight,
cardiac output, cardiomyopathy, heart iron levels |
Abnormal heart
morphology, weight, cardiac output, cardiomyopathy, heart iron
levels |
Abcb9 |
Small adrenal glands |
|
jax.org/reference/J:211773 |
Abcb10 |
Embryonic lethal, oxidative stress, abnormal
mitochondrial physiology |
Embryonic lethal, oxidative stress, abnormal
mitochondrial physiology |
Embryonic lethal, oxidative stress, abnormal
mitochondrial physiology |
Abcb11 |
Abnormal bile secretion, bile salt level, enlarged
liver, cholestasis |
Abnormal bile secretion, bile salt level, enlarged
liver, cholestasis |
|
Abcc1 |
Increased sensitivity to xenobiotics |
|
|
|
Decreased inflammatory response, mast cell physiology |
Decreased
inflammatory response, mast cell physiology |
|
Abcc2 |
Abnormal liver weight and physiology, bile secretion and
composition |
Abnormal liver weight and physiology, bile secretion and
composition |
Abnormal liver weight and physiology, bile secretion and
composition |
|
Increased sensitivity to xenobiotics |
|
|
Abcc3 |
Abnormal bile salt and bilirubin levels, bile salt
homeostasis |
Abnormal bile salt and bilirubin levels, bile salt
homeostasis |
|
|
Abnormal xenobiotic pharmacology |
|
|
Abcc4 |
Abnormal intestinal morphology, mucosa morphology and
inflammation |
Abnormal intestinal morphology, mucosa morphology and
inflammation |
Abnormal intestinal morphology, mucosa morphology and
inflammation |
|
Small spleen, thymus cortex hypoplasia |
|
|
|
Abnormal blood-brain barrier function |
|
|
Abcc5 |
Decreased circulating glucose level |
|
|
|
Decreased circulating eosinophils, leukocyte and lymphocytes |
Decreased circulating eosinophils, leukocyte and lymphocytes |
|
|
Limb grasping |
|
|
Abcc6 |
Calcified arteries and retina, calcified skin, decreased
HDL levels |
Calcified arteries and retina, calcified skin, decreased
HDL levels |
|
|
Abnormal vibrissa follicle morphology |
|
|
Cftr/Abcc7 |
Abnormal intestinal development, lacrimal gland
atrophy, pancreatic atrophy, |
Abnormal intestinal development, lacrimal
gland atrophy, pancreatic atrophy, |
Abnormal intestinal development,
lacrimal gland atrophy, pancreatic atrophy, |
|
Postnatal lethality |
|
|
|
Impaired fertilization, azoospermia, decreased litter size and sexual
maturation |
Impaired fertilization, azoospermia, decreased litter size
and sexual maturation |
Impaired fertilization, azoospermia, decreased
litter size and sexual maturation |
Abcc8 |
Hypoglycemia, abnormal insulin secretion, circulating
glucose |
Hypoglycemia, abnormal insulin secretion, circulating glucose |
|
Abcc9 |
Premature death |
|
jax.org/reference/J:216539 |
|
Hypoglycemia, increased insulin sensitivity |
|
jax.org/reference/J:71840 |
|
Hypertension |
|
jax.org/reference/J:78066 |
Abcc10 |
Decreased and abnormal spleen, decreased leukocytes and
bone marrow cells, and body weight |
Decreased and abnormal spleen,
decreased leukocytes and bone marrow cells, and body weight |
Decreased
and abnormal spleen, decreased leukocytes and bone marrow cells, and
body weight |
|
Thymus cortex hypoplasia |
|
|
Abcc12 |
nd |
|
|
Abcd1 |
Abnormal myelination, brain cell morphology,
astrocytosis, axon degeneration, impaired coordination |
Abnormal
myelination, brain cell morphology, astrocytosis, axon degeneration,
impaired coordination |
Abnormal myelination, brain cell morphology,
astrocytosis, axon degeneration, impaired coordination |
|
Cataract |
|
|
|
Increased fatty acid, levels, lipid homeostasis |
Increased fatty
acid, levels, lipid homeostasis |
|
|
Abnormal adrenal cortex morphology |
|
|
Abcd2 |
Neuronal and axon degeneration, ataxia, hyperactivity,
tremors, microglial cell morphology, posture, coordination |
Neuronal
and axon degeneration, ataxia, hyperactivity, tremors, microglial cell
morphology, posture, coordination |
Neuronal and axon degeneration,
ataxia, hyperactivity, tremors, microglial cell morphology, posture,
coordination |
Abcd3 |
Enlarged liver, abnormal bile composition |
|
|
Abcd4 |
Abnormal startle reflex, response to tactile stimulation,
new environment |
Abnormal startle reflex, response to tactile
stimulation, new environment |
Abnormal startle reflex, response to
tactile stimulation, new environment |
Abce1 |
Compete embryonic lethal |
|
|
Abcf1 |
Embryonic lethality prior to jax.organogenesis |
Embryonic lethality prior to jax.organogenesis |
jax.org/reference/J:245222 |
Abcf2 |
nd |
|
|
Abcf3 |
nd |
|
|
Abcg1 |
Abnormal blood cell levels, macrophage physiology,
cytokine secretion |
Abnormal blood cell levels, macrophage physiology,
cytokine secretion |
Abnormal blood cell levels, macrophage physiology,
cytokine secretion |
|
Hypoglycemia |
|
|
|
Hyperactivity, increased energy expenditure |
Hyperactivity, increased
energy expenditure |
|
Abcg2 |
Increased blood and urine uric acid, |
|
|
|
Abnormal mitochondria morphology and ox phos, porphyria |
Abnormal
mitochondria morphology and ox phos, porphyria |
|
Abcg3 |
nd |
|
|
Abcg4 |
Abnormal lipid level |
|
|
Abcg5 |
Premature death at 4-6 months |
trac allele |
jax.org/reference/J:157223 |
|
Abnormal lipid levels, bile secretion |
knockout |
jax.org/reference/J:87209 |
|
Male and female infertility |
|
|
Abcg8 |
Decreased cholesterol levels, circulating triglyceride
levels |
Decreased cholesterol levels, circulating triglyceride levels |
|