Figure Legends
Figure 1. Rate of loss-of-function mutations . The number of
loss-of-function mutations in the gnomAD database of exome and
whole-genome sequences is shown. The values are adjusted for gene size.
The ABCB7 and ABCD1 genes are on the X-chromosome.
Figure 2. Genes with individuals homozygous for loss-of-function
mutations. The number of full-transporters (FT) with at least one
individual with loss-of-function mutations is shown to that of other
genes (half-transporters and cytoplasmic). * P-value less than 0.05
(Actual P-value 0.012).