Figure Legends
Figure 1. Rate of loss-of-function mutations . The number of loss-of-function mutations in the gnomAD database of exome and whole-genome sequences is shown. The values are adjusted for gene size. The ABCB7 and ABCD1 genes are on the X-chromosome.
Figure 2. Genes with individuals homozygous for loss-of-function mutations. The number of full-transporters (FT) with at least one individual with loss-of-function mutations is shown to that of other genes (half-transporters and cytoplasmic). * P-value less than 0.05 (Actual P-value 0.012).